Drug addiction is regarded as the disease of the brain reward system which is considered a complex disease of the CNS. Morphine addiction involved not only counter adaptive changes of endogenous opioid peptides and its receptor system, but also adaptive changes of many non-opioid neuronal transmitter systems. This study reveiwed the neurobiology of morphine addiction, the neural mechanisms of addictive drugs that can be localized to a variety of brain regions and neuronal circuitry underlying the progressive increase in morphine relapse. Relapse can be modeled in laboratory animals by using conditioned place preference which widly is used from decades. This study also examined the role of nitric oxide (NO) in relapse to morphine dependence using the different NOS inhibitors e.g L-NAME, aminoguanidine, agmatine and NO precursor L-arginine significantly alter the morphine phenomenone.
Loading....